Journal article
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings
EJ Cheon, CE Bearden, D Sun, CRK Ching, OA Andreassen, L Schmaal, DJ Veltman, SI Thomopoulos, P Kochunov, N Jahanshad, PM Thompson, JA Turner, TGM van Erp
Psychiatry and Clinical Neurosciences | Published : 2022
DOI: 10.1111/pcn.13337
Abstract
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and 22q11.2 Deletion Syndrome (22q11DS) determined by ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium investigations. We obtained ranked effect sizes for subcortical volumes, regional cortical thickness, cortical surface area, and diffusion tensor imaging abnormalities, comparing each of these disorders relative to healthy controls. In addition, the studies report on significant associations between brain imaging metrics and disorder-related factors such as symptom severity and treatments. Visual comparison of effect size profiles shows t..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
The research studies produced by the ENIGMA Working Groups would not be possible without the contributions of many researchers across the globe and the authors of this review thank all scientists who contribute to making this work possible. A full list of ENIGMA Consortium current and past members can be found here http://enigma.ini.usc.edu/ongoing/members/.The authors acknowledge the NIH Big Data to Knowledge (BD2K) award for foundational support and consortium development (U54 EB020403 to PMT) and support from NIMH R01MH116147 (PMT), NIMH R01MH121246 (JAT, TGMvE, VDC), NIMH R01MH117601 (NJ, LS), NIMH R01MH085953 (CEB), NIMH R21MH116473 (CEB), NIMH 1U01MH119736 (CEB). For a complete list of ENIGMA-related grant support please see here: http://enigma.ini.usc.edu/about-2/funding.